Meso Boto-Xtreme – Sterile
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Targeted and result-oriented alternative to Botulinum
• Similar botulinum (Botox) effect
(also for Non-invasive treatment (not restricted to medical professionals) with, for example, MESOpower Pen or similar.)
*Training provided for approved practitioners and partners
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Meso Boto-xtreme Plus
Main Treatment Areas
Active Ingredients
MESO Boto Extreme – Advanced Peptide Infusion for Expression Lines
The MESO Boto Extreme is an advanced mesotherapy cocktail designed to soften expression lines, smooth surface texture, and restore skin firmness through next-generation peptide technology.
Developed and produced in Europe under ISO 9001 and ISO 13485 standards, this sterile cosmetic solution utilises bioactive peptides, amino acids, and hyaluronic acid to visibly refine the skin’s appearance — achieving a smoother, more relaxed look without invasive procedures.
Mechanism of Action
The formula is based on neurocosmetic peptides that modulate muscular tension at a cellular level while stimulating dermal matrix regeneration:
- Peptide Neuro-Relaxation – specific oligopeptides (including Acetyl Hexapeptide-8 and Pentapeptide-18) mimic the natural peptides involved in cellular communication, reducing the visible effects of repeated facial contractions.
- Collagen Renewal Support – DMAE and amino acids enhance fibroblast activity, improving firmness and elasticity.
- Hydration and Barrier Restoration – Hyaluronic Acid replenishes water balance, softening the surface and restoring a smoother, plumper texture.
This tri-phase approach delivers a visible improvement in skin smoothness and tone, particularly in dynamic areas such as the forehead, periocular region, and nasolabial folds.
Clinical Benefits
- Improves the appearance of fine lines and surface wrinkles
- Enhances skin firmness and elasticity
- Promotes a smoother, more even texture
- Supports hydration and dermal regeneration
- Non-invasive, sterile formulation suitable for mesotherapy or micro-infusion protocols
Scientific Formulation Highlights
| Key Active | Function |
|---|---|
| Acetyl Hexapeptide-8 | Reduces visible tension-related lines via neurocosmetic modulation |
| Pentapeptide-18 | Reinforces dermal elasticity and structural integrity |
| DMAE (Dimethylaminoethanol) | Enhances firmness and tonicity |
| Hyaluronic Acid (Low MW) | Provides deep hydration and suppleness |
| Amino Acid Complex | Supports protein synthesis and collagen renewal |
Application Protocol
Professional use only.
Delivered through mesotherapy, micro-infusion, or micro-needling techniques as part of a professional skin rejuvenation program.
For optimal results, treatments are typically performed in a series of 3–6 sessions at 10–14 day intervals, depending on skin condition and practitioner recommendation.
Always use sterile technique and single-use modules.
Professional Insight
MESO Boto Extreme represents a breakthrough in non-invasive peptide-based skin modulation, offering visible refinement and rejuvenation without the risks or downtime associated with more aggressive procedures.
Its synergy of acetyl hexapeptide, DMAE, and hyaluronic acid provides both immediate and progressive improvements in skin texture and tone, making it a preferred choice for clinics seeking a safe, evidence-backed, and client-friendly alternative in the age of non-traumatic aesthetics.
This formulation aligns with modern clinical trends toward natural, repeatable, and scientifically supported skin rejuvenation treatments — combining efficacy, safety, and profitability for professional use.
Regulatory Note
MESO Boto Extreme is a sterile cosmetic mesotherapy cocktail for professional use only. It is not a therapeutic or medicinal injectable and is not intended to diagnose, treat, or prevent any medical condition. All treatments must be performed in accordance with Australian regulations and within professional scope of practice.
Ingredients and their Functions:
Aqua (Water)
- Origin: Purified water.
- Effect: The base of the product, serving as a solvent for active ingredients. Contributes to hydration.
Retinol (Vitamin A)
- Origin: Synthetic or derived from natural sources such as fish or plants.
- Effect:
- Promotes cell renewal, resulting in smoother and more even skin.
- Reduces the appearance of fine lines and wrinkles.
- Improves skin texture and reduces pigmentation.
Ascorbic Acid (Vitamin C)
- Origin: Extracted from citrus fruits or produced synthetically.
- Effect:
- Powerful antioxidant that protects against free radicals.
- Brightens the skin and improves skin tone.
- Stimulates collagen production and reduces signs of aging.
Pentapeptide-3
- Origin: Synthetic peptide.
- Effect:
- Improves skin firmness and elasticity.
- Enhances collagen synthesis and reduces wrinkles.
Acetyl Hexapeptide-8
- Origin: Synthetically produced.
- Effect:
- Known as a “Botox-like” peptide.
- Reduces muscle contractions, thereby diminishing fine lines and wrinkles.
Acetyl Octapeptide-3
- Origin: Synthetic peptide.
- Effect:
- Reduces muscle activity and minimizes the appearance of wrinkles.
- Supports skin firmness and elasticity.
Sodium Hyaluronate
- Origin: Derived from hyaluronic acid through fermentation.
- Effect:
- Provides intense hydration by attracting moisture to the skin.
- Plumps the skin, reducing fine lines and imparting a more youthful glow.
Avena Sativa Extract (Oat Extract)
- Origin: Extracted from oat kernels.
- Effect:
- Soothes and calms the skin with anti-inflammatory properties.
- Reduces irritation and redness.
Zinc Chloride
- Origin: Chemically produced.
- Effect:
- Regulates sebum production and prevents clogged pores.
- Strengthens the skin’s barrier and protects against environmental damage.
Copper Gluconate
- Origin: Combination of copper and gluconic acid.
- Effect:
- Supports collagen synthesis.
- Has antioxidant properties that protect the skin from aging.
Cobalt Gluconate
- Origin: Combination of cobalt and gluconic acid.
- Effect:
- Boosts the skin’s energy and metabolism.
- Contributes to a more radiant complexion.
Arginine Aspartate
- Origin: Amino acids from plants or synthetically produced.
- Effect:
- Promotes skin regeneration and elasticity.
- Contributes to skin hydration and cell renewal.
Valine
- Origin: Essential amino acid found in protein-rich foods like beans and grains.
- Effect:
- Aids in tissue repair and strengthens the skin’s structure.
Pyridoxine (Vitamin B6)
- Origin: Found in foods such as fish and bananas, or produced synthetically.
- Effect:
- Regulates sebum production and promotes healthy skin.
- Soothes irritation and reduces acne.
Thiamine HCL (Vitamin B1)
- Origin: Found in whole grains or synthetically produced.
- Effect:
- Protects against oxidative stress and prevents premature aging.
- Supports the skin’s natural repair processes.
Sodium Chloride
- Origin: Naturally occurring salt.
- Effect:
- Stabilizes the product’s viscosity.
- Improves the formulation’s stability.
Sodium Hydroxide
- Origin: Synthetically produced.
- Effect:
- Adjusts the pH level to ensure skin tolerance.
Anti-age Properties:
These ingredients work together to hydrate, stimulate collagen production, improve skin elasticity, and protect against oxidative stress, resulting in more youthful, firm, and radiant skin.
List of Active Ingredients with their Origin, Effect, and Anti-aging Properties:
Pentapeptides, Hexapeptides, and Octapeptides
- Origin: Synthetically produced small chains of amino acids.
- Effect:
- Reduce fine lines and wrinkles by inhibiting muscle contractions.
- Improve skin firmness and elasticity by stimulating collagen production.
- Promote smoother, more youthful-looking skin.
EGF (Epidermal Growth Factor)
- Origin: Biotechnologically produced protein that mimics the body’s own growth factors.
- Effect:
- Stimulates the growth and regeneration of skin cells by binding to epidermal growth factor receptors.
- Improves cell renewal, healing, and strengthens the skin’s structure.
- Reduces signs of aging and enhances the skin’s regenerative capacity.
Ferulic Acid
- Origin: Naturally found in the cell walls of plants such as rice, wheat, and oats.
- Effect:
- Powerful antioxidant that protects the skin against oxidative stress and UV damage.
- Reduces pigmentation and brightens the skin by inhibiting melanin production.
Ubiquinone (Coenzyme Q10)
- Origin: Naturally occurring antioxidant in the body, also produced synthetically for cosmetics.
- Effect:
- Protects the skin from free radicals and environmental damage.
- Improves the strength and elasticity of cell membranes.
- Supports cell renewal and reduces visible signs of aging.
Sodium DNA
- Origin: Extracted from natural sources, often fish DNA.
- Effect:
- Deeply moisturizes and promotes cell renewal.
- Rebuilds connective tissue and strengthens the skin’s structure.
- Effective for skin healing and regeneration, especially with technologies like mesopen and ultrasound.
Hyaluronic Acid (Sodium Hyaluronate)
- Origin: Produced through biotechnology, often via bacterial fermentation.
- Effect:
- Binds water to the skin, providing intensive moisture.
- Improves skin volume and elasticity, reducing wrinkles and fine lines.
- Leaves the skin smooth, plump, and youthful.
Avena Sativa (Oat Extract)
- Origin: Extracted from oat kernels.
- Effect:
- Soothes the skin and reduces inflammation.
- Protects against environmental damage and strengthens the skin’s natural barrier.
- Moisturizes and calms irritated skin.
Lecithin, Phytosterols, and Fatty Acids
- Origin: Extracted from soybeans or sunflower seeds.
- Effect:
- Improves the skin’s barrier and reduces moisture loss.
- Regenerates damaged tissue and strengthens skin elasticity.
- Supports the skin’s structure, providing a softer, smoother surface.
Anti-aging Properties
These active ingredients work synergistically to:
- Reduce wrinkles and improve skin elasticity.
- Protect against free radicals and UV damage.
- Improve cell renewal and regeneration.
- Provide intense moisture and strengthen the skin’s barrier, resulting in firm, smooth, and youthful skin.
Overall Effect of the Formula
- Promotes stem cell proliferation and regeneration of damaged tissue.
- Reduces signs of aging such as wrinkles and fine lines.
- Improves the skin’s moisture, texture, and appearance.
- Strengthens the skin’s natural barrier and provides intensive hydration.
These ingredients work synergistically to provide healthy, youthful, and revitalized skin.
Treatment Areas and Results
Treatment Areas:
- Face:
- Reduces fine lines and wrinkles.
- Improves skin firmness and elasticity.
- Brightens the skin and minimizes pigmentation.
- Neck:
- Tightens the skin and reduces visible signs of aging.
- Gives the skin a more youthful appearance.
- Décolleté:
- Enhances skin texture and hydration.
- Strengthens the skin barrier and reduces dryness.
Results:
- Intensive Hydration:
- Ingredients like Sodium DNA and hyaluronic acid bind moisture to the skin, leaving it smooth and hydrated.
- Ceramides and squalane help strengthen the skin barrier and retain moisture.
- Reduced Aging:
- EGF (Epidermal Growth Factor): Stimulates cell renewal and regenerates damaged tissue, reducing wrinkles and fine lines.
- Ferulic Acid: Protects against UV damage and oxidative stress, which accelerates skin aging.
- Skin Tightening:
- Promotes collagen production for firmer and more elastic skin.
- Strengthens connective tissue and improves skin firmness.
- Improved Skin Texture:
- Ubiquinone (Coenzyme Q10): Enhances elasticity and strengthens cell membranes, creating smoother, more even skin.
- Brightens the skin by reducing melanin production and evening out pigmentation.
- Strengthened Skin Barrier:
- Ingredients like lecithin, phytosterols, and shea butter help rebuild the skin’s natural protection.
- Regeneration of Damaged Tissue:
- Sodium DNA: Repairs damaged skin cells and promotes healing, improving the skin’s overall health.
Recommendation:
For optimal penetration and maximum results, this treatment can be combined with technologies such as:
- Electroporation
- Ultrasound
- Mesopen or Mesoroller
These technologies enhance the effectiveness of active ingredients by ensuring deeper penetration into the skin.
Mesoskinline Invasive (Sterile) Protocol Overview
Mesoskinline Invasive Protocols are sterile, European-formulated mesotherapy treatments designed for use by qualified doctors and registered nurses.
These sterile cocktails deliver active ingredients directly into the dermis for visible skin correction, hydration, and lifting — using safe, standardised techniques and precise equipment.
MESO Pure Peel — Pre-Treatment Preparation
Each treatment begins with MESO Pure Peel, a professional pre-treatment formula that:
- Deeply cleanses and degreases the skin
- Balances pH for improved serum absorption
- Reduces bacterial load and irritation risk
- Creates a sterile, optimised surface for injection or infusion
This step is essential for achieving consistent results and maintaining strict aseptic standards.
MESO Cocktail Infusion — Targeted Delivery
The practitioner selects a sterile MESO cocktail based on indication
(Fresh Vitamin+, Cheek Lift+, Eye Lift+, Hair Loss Control+, Stretch Mark Remover+, BOTO-Xtreme+, etc.).
Infusion can be performed using one of three delivery options:
Delivery Methods
Manual Injection:
Point-by-point, nappage, or linear retrograde techniques
Needle depth 1–6 mm depending on area
Typical dose: 2–8 mL per session
MESOpower® Pen:
Controlled percutaneous infusion with sterile 3, 11, or 36-point modules
Ideal for uniform diffusion and reduced trauma
Leadergun:
Automated mesotherapy injector for rapid, even delivery over large or targeted areas
These systems allow clinicians to select the most efficient and comfortable delivery mode for the patient and indication.
Massage & Diffusion Phase
After infusion, gentle manual massage promotes even distribution of the actives, stimulates microcirculation, and enhances absorption through the dermis.
MESO Bio-Cellulose Mask — Cooling & Regeneration
Apply the MESO Bio-Cellulose Mask to calm and cool the skin, minimise erythema, and lock in hydration.
This mask is infused with peptides, HA, and antioxidants to accelerate recovery, leaving the skin radiant and balanced immediately post-procedure.
It can also be paired with LED or Cold Jet Plasma for enhanced post-injection healing.
MESO Lift & Protect 50+ — Finishing Barrier
Complete the treatment with MESO Lift & Protect 50+, a hydrating, antioxidant SPF 50+ finishing cream that strengthens the barrier, prevents inflammation, and supports ongoing skin repair.
***Do not mix Mesoskinline cocktails with other brands or add actives to vials.
Treatment Frequency
Every 10–14 days for 4–6 sessions (depending on indication)
Maintenance: Every 2–3 months for lasting results
Technology Compatibility
Mesoskinline invasive protocols can be safely integrated with:
- HIFU (High-Intensity Focused Ultrasound)
- Radio Frequency (RF) Microneedling or Tightening
- Cold Jet Plasma
- LED Phototherapy
**Do not mix Mesoskinline cocktails with other brands or add actives to vials.
MESO Professional Peels (in alternating sessions)
These modalities enhance collagen synthesis, elasticity, and cellular renewal, delivering advanced, layered rejuvenation outcomes.
Safety & Quality
- Sterile, single-use EU-manufactured vials
- Produced under ISO 9001 and ISO 13485 medical device standards
- Formulated with non-crosslinked hyaluronic acid, peptides, vitamins, and antioxidants
- CE-marked, traceable, and compliant with EU cosmetic-medical safety directives
Expected Clinical Results
- Improved hydration, elasticity, and tone
- Reduction of fine lines and wrinkles
- Restored firmness and luminosity
- Enhanced skin structure and barrier integrity
