Meso Exocell Volume

Item No: MST103

Pack: 5 x 5 ml vials + 5 x transparent pipettes

Treatments: 5

Main Treatment Areas

Face
Eye Area
Neck
Hands
Acne Scars & Uneven Texture

Active Ingredients

Syn®-Ake: Temporarily inhibits muscle contractions and reduces expression wrinkles safely and non-invasively
Bio-Authentic Exosomes: Stimulates skin regeneration
Vitamins E, C, and A: Protects and strengthens the skin

Ingredients

Aqua (Water)
• Description: Purified, de-ionised water base
• Origin: Distilled/filtered water
• Function: Universal solvent / carrier, provides basic hydration
Glycerin
• Description: Trivalent sugar alcohol (classic humectant)
• Origin: Vegetable oils (rapeseed/soy) or biodiesel by-product
• Function: Binds water in the stratum corneum → “plumps” dehydration lines
Phospholipids
• Description: Skin-identical phospholipids (lecithin fraction)
• Origin: Extracted from soy or sunflower lecithin
• Function: Repairs lipid barrier, forms lamellar structures, increases penetration of actives
Citrullus Lanatus (Watermelon) Fruit Extract
• Description: Fruit extract rich in lycopene, minerals and amino acids
• Origin: Watermelon flesh/rind (food by-product)
• Function: Antioxidant protection against UV-ROS, light hydration and soothing
Citrus Paradisi (Grapefruit) Fruit Extract
• Description: Extract containing AHAs and vitamin C
• Origin: Cold-pressed peel and pulp of grapefruit
• Function: Mild chemical exfoliation, antibacterial, fresher complexion
Momordica Charantia Fruit Extract
• Description: Bitter-melon extract with charantin & momordicin
• Origin: Fruit of Momordica charantia
• Function: Anti-inflammatory, prebiotic; calms redness & strengthens microbiome
Phenoxyethanol
• Description: Aromatic alcohol preservative
• Origin: Synthetic (petro-/phenol origin)
• Function: Broad-spectrum antimicrobial – ensures product shelf life
Xanthan Gum
• Description: Natural polysaccharide gel
• Origin: Fermentation of corn or sugar-molasses (Xanthomonas bacteria)
• Function: Thickening; stabilises viscosity and prevents phase separation
Sodium Lactate
• Description: Sodium salt of lactic acid; part of the skin’s NMF
• Origin: Fermentation of sugar beet/corn
• Function: Humectant, slight pH-buffering effect
PCA (Pyrrolidone Carboxylic Acid)
• Description: Organic acid – natural moisturising factor
• Origin: Biosynthesis from glutamic acid
• Function: Binds moisture; keeps skin supple and elastic
Sodium PCA
• Description: Sodium salt of PCA (more water-soluble)
• Origin: As above, neutralised with NaOH
• Function: Extra-high moisture binding; counteracts tightness
Arginine
• Description: Basic α-amino acid
• Origin: Fermentation of sugarcane/corn
• Function: pH-buffer, moisturiser, supports wound-healing & micro-circulation
Ethylhexylglycerin
• Description: Multifunctional emollient / preservative booster
• Origin: Vegetable glycerol + ethylhexyl group (semi-synthetic)
• Function: Enhances phenoxyethanol, softens skin surface
Aspartic Acid
• Description: Acidic amino acid in NMF
• Origin: Microbial fermentation
• Function: Maintains moisture balance; substrate for protein synthesis (collagen)
Disodium EDTA
• Description: Chelating agent (salt of ethylenediaminetetraacetic acid)
• Origin: Synthetic
• Function: Binds metal ions → stabilises formula & preservation system
Sorbitol
• Description: Hexavalent sugar alcohol
• Origin: Hydrolysis / hydrogenation of corn- or potato-starch
• Function: Humectant; reduces drying-out and crystallisation
Lecithin
• Description: Mixed phospholipids (PC, PE etc.)
• Origin: Soybeans or sunflower seeds
• Function: Natural emulsifier; repairs barrier; improves penetration
Citric Acid
• Description: Alpha-hydroxy acid (AHA)
• Origin: Citrus fruits or fermentation of sugar-molasses
• Function: Adjusts pH; very mild exfoliation; refines skin surface
Tocopheryl Acetate (Vitamin E)
• Description: Stable ester of tocopherol
• Origin: Esterified vitamin E from plant oils
• Function: Fat-soluble antioxidant – protects membrane lipids & collagen
Amino-acid blend (Phenylalanine, Valine, Serine, Threonine, Glycine, Histidine, Alanine, Proline, Isoleucine)
• Origin: Fermentation of glucose/corn (biotechnological)
• Function: Building blocks for collagen & elastin; increase moisture and elasticity
Dipeptide Diaminobutyroyl Benzylamide Diacetate (Syn-Ake)
• Description: Synthetic tripeptide that mimics snake venom
• Origin: Chemical synthesis (peptide laboratory)
• Function: Temporary neuromuscular inhibition ⇒ botox-like smoothing of expression lines
Glyceryl Linoleate
• Description: Ester of glycerin + linoleic acid (omega-6)
• Origin: Safflower- or sunflower-oil (pre-saponification / esterification)
• Function: Repairs lipid barrier; calms inflammation; increases suppleness
Glyceryl Linolenate
• Description: Ester of glycerin + α-linolenic acid (omega-3)
• Origin: Flaxseed- or rapeseed-oil
• Function: Anti-inflammatory; soothes irritation; strengthens barrier
Sodium Ascorbyl Phosphate
• Description: Water-soluble, stable vitamin C derivative
• Origin: Synthetic (ascorbic acid + phosphate + sodium)
• Function: Antioxidant; stimulates collagen; brightens dark spots
Retinyl Palmitate
• Description: Ester of retinol + palmitic acid (vitamin A derivative)
• Origin: Synthetic / plant-derived
• Function: Increases cell turnover; smooths skin; regulates sebum; boosts collagen
Potassium Sorbate
• Description: Salt of sorbic acid (mild preservative)
• Origin: Synthetic (originally sorbic acid from rowan berries)
• Function: Inhibits yeast and mould – keeps product safe

Synergy for anti-age
The combination of Syn-Ake (rapid smoothing) + vitamins A/C/E (long-term rebuilding & antioxidant) + amino acids & lipids (barrier/collagen support) + plant-extract antioxidants provides both immediate and lasting improvements in lines, firmness and skin tone, while helping prevent future signs of ageing.

The technique behind the production of MESO EXOCELL VOLUME

Phase	What happens	Why it’s important
1. Cell source & cultivation	Human, skin-compatible progenitor cells (non-embryonic) are used.Cultured in a closed, serum-free medium under GMP conditions to avoid animal contaminants.	Creates “bio-authentic” exosomes with the same lipid signature and signalling proteins as the skin’s own.
2. Harvest & isolation of exosomes	The culture undergoes mild ultracentrifugation, tangential-flow filtration (TFF) and micro-fluidic size-exclusion.Vesicles 30-150 nm are collected while larger debris is removed.	Provides high purity (>95 %) and intact membrane structure → optimal cell communication.
3. Characterisation & QC	Nanoparticle Tracking Analysis (NTA) measures particle size and concentration.Western blot / ELISA confirms exosome markers (CD63, CD81, TSG101).Endotoxin, mycoplasma and sterility tests are performed.	Documents that exosomes are safe, sterile and biologically active.
4. Lyophilisation & stabilisation	Exosomes are mixed with cryoprotectants (trehalose, sucrose) and freeze-dried at −40 °C / <10⁻³ mbar.The result is a stable, hygroscopic powder retaining >90 % bioactivity after rehydration.	Makes the product shelf-stable at 2–8 °C and resistant to transport stress.
5. Peptide synthesis (Syn-Ake)	The tripeptide is synthesised via solid-phase peptide synthesis (SPPS) with Fmoc chemistry.Purified by RP-HPLC to >98 % purity and tested for heavy metals / solvent residues.	Ensures consistent neuromuscular inhibition (botox-like) without immunogenicity.
6. Formulation (nano-emulsion)	Lyophilisate of exosomes, Syn-Ake, vitamin E acetate, glycerin and phospholipids are dissolved in buffer and emulsified by low-shear ultrasonics.pH adjusted to 6.2–6.5 (skin-neutral).	Forms a stable nano-emulsion; phospholipids help exosomes and peptides pass through the stratum corneum.

Key points in the technology

Bio-authentic exosome delivery system™ – mimics natural cell communication, boosts fibroblast glycolysis and collagen production.
Peptide/exosome synergy – Syn-Ake reduces micro-contractions while exosomes stimulate tissue building → double anti-age effect.
Lyophilisation + phospholipid nano-emulsion – combines long shelf life with high cutaneous penetration without needles.

Treatment Areas and Results with Meso Eye Lift

Treatment Areas:

Face, especially the eye area: The delicate skin around the eyes is often one of the first areas to show signs of aging. This treatment is specifically designed to tighten and improve skin elasticity in this region.
Entire face: In addition to the eye area, the treatment can also be applied to other parts of the face to restore a more youthful facial contour, even out skin tone, and reduce irregularities.
Stressed, dull, or neglected skin (also suitable for neck and hands): The treatment benefits individuals who have exposed their skin to smoking, lack of care, or other stress factors, by improving the skin’s overall appearance and vitality.

Treatment Areas and Results Using Meso EXOCELL

Treatment Areas

Face – reduces fine lines and wrinkles, adds radiance and firmness
Neck & décolletage – tightens and rejuvenates the delicate skin of the chest and neck area
Hands – improves skin texture, evens tone and diminishes visible signs of aging
Eye area – smooths expression lines (“crow’s-feet”) and reduces signs of fatigue
Acne scars & uneven skin texture – stimulates cell renewal, promotes healing and smooths scars
Early signs of aging – preventive treatment for younger skin to preserve elasticity

Results Using MESO EXOCELL

Immediate reduction of fine lines – The Syn-Ake peptide provides Botox-like smoothing after just one treatment.
Improved skin texture & more even complexion – gentle AHAs and vitamin C smooth the surface and minimize pores.
Visible tightening & renewed volume – increased collagen/elastin creates firmer contours and a “plumped” look.
Instant radiance & increased elasticity – moisture binding plus exosome-driven cellular energy delivers fresh, glowing skin.
Strengthened skin barrier – phospholipids, omega fatty acids and amino acids reduce moisture loss and boost resilience.
Reduced redness & inflammation – bitter-melon extract and prebiotic exosomes balance the microbiome and calm irritation.

Recommended Treatment Course

Course: 4–5 treatments at roughly 10-day intervals for optimal collagen stimulation and tissue renewal.
Maintenance: 1 follow-up session every 3–4 months to maintain results and prevent new signs of aging.

Mesoskinline Non Invasive Microneedling Protocol Overview

*Training provided for all practioners and partners

Mesoskinline is a European-engineered mesotherapy and microneedling system designed for professional use by qualified doctors, nurses, and dermal clinicians. Developed in Italy and Denmark and distributed in over 100 countries worldwide, the system combines clinical efficacy, safety, and commercial performance — allowing practitioners to deliver visible skin improvement without injections or downtime.

Protocol Structure

Each treatment follows a structured clinical sequence designed to optimise skin preparation, absorption, and recovery.
All cocktails are sterile, single-use, and manufactured under ISO 9001 and ISO 13485 medical device standards.

Step 1. MESO Pure Peel — Professional Skin Preparation

The treatment begins with MESO Pure Peel, a medical-grade degreasing and balancing solution.
It deeply cleanses, gently exfoliates, and rebalances the skin’s pH to prepare the epidermis for uniform serum infusion.
This step enhances the penetration of actives, improves safety, and ensures consistent, sterile treatment conditions.

Step 2. MESO Cocktail Infusion — Targeted Delivery

The selected MESO cocktail is infused using the MESOpower® Pen, with a choice of four sterile modules:

24 Polymer (non-invasive) – for spa-safe infusion and sensitive skin
11-Point – gentle epidermal stimulation and enhanced absorption
36-Point – high-density collagen activation and serum diffusion
3-Point – precision delivery for lifting, contouring, and targeted zones

Depth settings typically range from 0.25–0.8 mm, depending on the treatment area and protocol indication.
Practitioners use Circular Motion as the standard technique, or Press & Lift for advanced, precision infusion and lifting protocols (including the upcoming Accu-Lifting system).

Step 3. MESO Bio-Cellulose Mask — Recovery & Hydration Phase

Following infusion, the skin is treated with the MESO Bio-Cellulose Mask, a cooling, peptide-enriched finishing step.
It immediately reduces redness, rehydrates, and accelerates barrier repair.
The mask enhances the penetration of infused actives, providing a luminous, glass-skin finish.
This step can be combined with LED or Cold Jet Plasma to intensify post-treatment results.

Step 4. MESO Lift & Protect 50+ — Finishing Barrier

The final step is MESO Lift & Protect 50+, a multifunctional finishing cream providing hydration, antioxidant protection, and SPF 50+.
It seals in results, protects from UV and oxidative stress, and leaves the skin perfectly balanced post-procedure.

Clinical Timing & Frequency

Treatments are performed every 10–14 days in progressive series of 3–6 sessions.
Results are cumulative and can be maintained with booster sessions every 3–4 months.
The system integrates seamlessly into existing clinical treatment menus for both face and scalp.

Advanced Modality Integration

Mesoskinline protocols are engineered for synergy and can be layered or combined with other technologies for superior outcomes.
Compatible With:

HIFU (High-Intensity Focused Ultrasound) for lifting and contouring
MESO Professional Peels for surface refinement
LED Phototherapy for recovery and enhanced ATP stimulation
Radio Frequency (RF) for collagen tightening
Cold Jet Plasma for enhanced transdermal delivery and healing response

These modalities may be performed in the same session or in alternating treatment cycles, depending on protocol intensity and client goals.

Why Clinics Choose Mesoskinline

ISO 9001 & ISO 13485 certified manufacturing in Europe
Clinically tested and globally trusted across 100+ countries
Non-invasive, sterile, high-return treatment system
Compatible with medical and advanced aesthetic equipment
Ideal for doctors, nurses, and dermal clinicians seeking repeatable results with no downtime

Results & Outcomes

Improved skin firmness and elasticity
Deep hydration and smoother texture
Reduction in fine lines and uneven tone
Enhanced product absorption and skin integrity
Instant post-treatment radiance with no irritation or trauma

Meso Exocell Volume- Microneedling Cocktail